CBG, or Cannabigerol, is an extract of the cannabis plant that offers many benefits to its users. CBG may provide relief from chronic pain and inflammation, reduce nausea caused by Zofran (ondansetron) treatment, relieve symptoms associated with epilepsy and multiple sclerosis, treat psoriasis and eczema, combat heart disease and diabetes, fight off cancerous cells in breast cancer patients by reducing the size of tumors, slow the progress of Alzheimer’s disease by removing amyloid plaques found in brain nerve cells known as neurons, protect brain cells from damage during a stroke, prevent seizures, improve mood disorders including depression, help people sleep better at night, ease endometriosis symptoms, and reduce the appearance of acne.

CBG gummies are CBG-infused gelatin confections that are usually in the shape of bears, fruit, or other fun shapes. CBG is a cannabinoid produced in cannabis by various strains of marijuana. CBG gummies have become popular throughout the United States due to their ability to provide relief from many common ailments, but how do they work?

CBD and endocannabinoid system (ECS)

The body’s endocannabinoid system (ECS) regulates pain, mood, memory, appetite, stress levels, organ function, immunity, hormones, and more. The ECS consists of lipid signaling molecules found throughout the body: CB1 receptors which mainly exist in neurons and their connecting structures; and CB2 receptors which mainly exist on immune cells and their connecting structures. CBG interacts with CB1 receptors to regulate pain, mood, memory, appetite, stress levels, organ function, immunity, hormones, blood pressure, bone mass, the immune system (which causes CBG gummies to be helpful when combating colds or flu), inflammation.

CBG also interacts with CB2 receptors in the endocannabinoid pathway to regulate heart rate, blood pressure, bone mass, immune function (CBG is believed to help prevent the activation of microglia at sites of nerve injury in mice). CBG can also interact with serotonin 5-HT 1A receptors within the brain’s serotonin system to reduce anxiety and improve mood disorders like depression through anandamide signaling pathways.

One way CBG may benefit people is by producing an anti-inflammatory effect on the body. This occurs because CBG inhibits the activity of a group of enzymes called fatty acid amide hydrolase (FAAH) which breaks down naturally occurring endocannabinoids within the body known as anandamide and 2-Arachidonoylglycerol (2AG). CBG also reduces inflammation by suppressing immune cells called macrophages from producing pro-inflammatory signals such as interleukin (IL)-6 and IL-1B, and by enhancing macrophage activity. CBG can also suppress inflammation by activating adenosine receptors on immune cells. CBG is also believed to reduce the toxicity of certain chemotherapy medications and therefore enhance their effect. CBG gummies may help prevent cancerous cells from reproducing in breast cancer patients if CBG effectively binds with CB2 cannabinoid receptors on the surface of tumors.

CBG has been shown to promote the death, or apoptosis, of these cells while protecting healthy cells from damage. CBG dosing guidelines for this use may vary depending on the individual’s overall health profile, but dosing guidelines for epilepsy suggest doses of 25mg three times daily as necessary to reduce seizures.

Best CBG gummies are a safe and effective way to promote overall wellness and CBG’s effects may take longer than CBG oil or CBG capsules to be noticeable; however, CBG gummies also come in THC-free varieties that can be shipped anywhere in the US without breaking any CBG federal laws (THC is the psychoactive cannabinoid present in high levels within marijuana which can get you high).

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